Phototherapy, the use of light for healing, has in recent years been a field of advanced multidisciplinary treatments. It has been proven to be beneficial in a wide and diverse array of applications including the healing of chronic and acute wounds. Phototherapy using low-energy red laser lights and red LED arrays (640–690 nm; 670-nm peak) is now being used in a variety of clinical settings to promote wound healing and tissue regeneration. At the cellular level, photoirradiation at low fluences can generate significant biological effects, including cellular proliferation and the release of growth factors from cells.